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Article

Inhibitory KIRs decrease HLA class II-mediated protection in Type 1 Diabetes.

PLoS genetics - 1 Dec 2024

Mora-Bitria Laura, Debebe Bisrat J, Miners Kelly L, Ladell Kristin, Kaur Charandeep, Traherne James A, Jiang Wei, Price David A, Hadcocks Linda, McQuibban Nicholas A R, Trowsdale John, Wong F Susan, Pontikos Nikolas, Niederalt Christoph, Asquith Becca

Abstract excerpt

Inhibitory killer cell immunoglobulin-like receptors (iKIRs) are a family of inhibitory receptors that are expressed by natural killer (NK) cells and late-stage differentiated T cells. There is accumulating evidence that iKIRs regulate T cell-mediated immunity. Recently, we reported that T cell-mediated control was enhanced by iKIRs in chronic viral infections. We hypothesized that in the context of autoimmunity,...

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Share to Autoimmunity
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Diabetes Mellitus, Type 1

Share to Genetic Predisposition to Disease

Share to Histocompatibility Antigens Class II

Share to Killer Cells, Natural

Share to Receptors, KIR

Share to T-Lymphocytes

Source

Open in PubMed Open full text

Identifiers

PMID: 39724143
DOI: 10.1371/journal.pgen.1011456
PMCID: PMC11741628

Genes

CD4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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Inhibitory KIRs decrease HLA class II-mediated protection in Type 1 Diabetes.PMID 39724143Read ↗

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