Article
NK Cell Subsets Changes in Partial Remission and Early Stages of Pediatric Type 1 Diabetes.
Frontiers in immunology - 1 Jan 2020
Gomez-Muñoz Laia, Perna-Barrull David, Villalba Adrian, Rodriguez-Fernandez Silvia, Ampudia Rosa-Maria, Teniente-Serra Aina, Vazquez Federico, Murillo Marta, Perez Jacobo, Corripio Raquel, Bel Joan, Vives-Pi Marta
Abstract excerpt
Type 1 diabetes (T1D) is a chronic metabolic disease characterized by the autoimmune destruction of β-cells in the pancreatic islets. T1D is preceded by islet-specific inflammation led by several immune cells. Among them, natural killer (NK) cells are emerging as important players in T1D development. Human NK cells are characterized by CD56 and CD16 expression, which allows classifying NK cells into four subsets:...
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