Inhibitory KIRs decrease HLA class II-mediated protection in Type 1 Diabetes

Abstract excerpt

Inhibitory killer cell immunoglobulin-like receptors (iKIRs) are a family of inhibitory receptors that are expressed by natural killer cells and late-stage differentiated T cells. There is accumulating evidence that iKIRs regulate T cell-mediated immunity. Recently, we reported that T cell-mediated control was enhanced by iKIRs in chronic viral infections. We hypothesized that in the context of autoimmunity, where...

Topics

Open a Topic to create a Post that cites this publication.

• Autoimmunity
• Case-Control Studies
• Diabetes Mellitus, Type 1
• Genetic Predisposition to Disease
• Histocompatibility Antigens Class II
• Killer Cells, Natural
• Receptors, KIR
• T-Lymphocytes

Identifiers and source

Literature Corpus work

1dc5e053-c836-57aa-9a8d-d6a397545fa9

DOI

10.1101/2024.03.27.586933