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Bacterial Peptidoglycan‐Associated Lipoprotein: A Naturally Occurring Toll‐Like Receptor 2 Agonist That Is Shed into Serum and Has Synergy with Lipopolysaccharide

16 Feb 2005

Abstract excerpt

Sepsis is initiated by interactions between microbial products and host inflammatory cells. Toll-like receptors (TLRs) are central innate immune mediators of sepsis that recognize different components of microorganisms. Peptidoglycan-associated lipoprotein (PAL) is a ubiquitous gram-negative bacterial outer-membrane protein that is shed by bacteria into the circulation of septic animals. We explored the...

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PMID: 15717270
DOI: 10.1086/427815

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