Article
Haptoglobin Phenotype Modifies the Influence of Intensive Glycemic Control on Cardiovascular Outcomes.
Journal of the American College of Cardiology - 11 Feb 2020
Carew Allie S, Levy Andrew P, Ginsberg Henry N, Coca Steven, Lache Orit, Ransom Thomas, Byington Robert, Rimm Eric B, Sapp John, Gardner Martin, Cahill Leah E
Abstract excerpt
BACKGROUND: Whereas there exists a direct relationship between glycated hemoglobin and cardiovascular disease (CVD), clinical trials targeting glycated hemoglobin to near-normal levels using intensive therapy have failed to prevent CVD and have even increased mortality, making clinical decision making difficult. A common polymorphism at the haptoglobin (Hp) genetic locus is associated with CVD, especially...
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