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The Relationship Between Time-Varying Achieved HbA1c and Risk of Coronary Events Depends on Haptoglobin Phenotype Among White and Black ACCORD Participants.

Diabetes care - 1 Nov 2023

Cahill Leah E, Warren Rachel A, Carew Allie S, Levy Andrew P, Ginsberg Henry N, Sapp John, Lache Orit, Rimm Eric B

Abstract excerpt

OBJECTIVE: Intensive glycemic therapy reduced coronary artery disease (CAD) events among White participants in the Action to Control Cardiovascular Risk in Diabetes (ACCORD) study with the haptoglobin (Hp)2-2 phenotype, while participants without the Hp2-2 phenotype had no CAD benefit. The association between achieved glycated hemoglobin (HbA1c) and CAD for each Hp phenotype remains unknown. RESEARCH DESIGN AND...

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Identifiers

PMID: 37639669
DOI: 10.2337/dc23-0760

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