Article
Relationship Between Time-Varying Achieved High-Density Lipoprotein Cholesterol and Risk of Coronary Events Depends on Haptoglobin Phenotype Within the ACCORD Lipid Study.
Journal of the American Heart Association - 3 Oct 2023
Warren Rachel A, Carew Allie S, Andreou Pantelis, Levy Andrew P, Sapp John, Lache Orit, Ginsberg Henry N, Rimm Eric B, Herman Christine, Kirkland Susan, Cahill Leah E
Abstract excerpt
Background The Hp (haptoglobin)2-2 phenotype (~40% of people) is associated with dysfunctional high-density lipoprotein (HDL) that is heavily oxidized in hyperglycemia, which may explain why raising HDL-cholesterol (HDL-C) does not reliably prevent coronary artery disease (CAD) in diabetes. Methods and Results In this observational study using longitudinal data from the ACCORD (Action to Control Cardiovascular...
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