Article
Recognition of polyadenosine RNA by the zinc finger domain of nuclear poly(A) RNA-binding protein 2 (Nab2) is required for correct mRNA 3'-end formation.
The Journal of biological chemistry - 20 Aug 2010
Kelly Seth M, Leung Sara W, Apponi Luciano H, Bramley Anna M, Tran Elizabeth J, Chekanova Julia A, Wente Susan R, Corbett Anita H
Abstract excerpt
Proteins bound to the poly(A) tail of mRNA transcripts, called poly(A)-binding proteins (Pabs), play critical roles in regulating RNA stability, translation, and nuclear export. Like many mRNA-binding proteins that modulate post-transcriptional processing events, assigning specific functions to Pabs is challenging because these processing events are tightly coupled to one another. To investigate the role that a...
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