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Article

tbCPSF30 depletion by RNA interference disrupts polycistronic RNA processing in Trypanosoma brucei.

The Journal of biological chemistry - 18 Jul 2003

Hendriks Edward F, Abdul-Razak Ammar, Matthews Keith R

Abstract excerpt

Gene expression in eukaryotes requires the post-transcriptional cleavage of mRNA precursors into mature mRNAs. In Trypanosoma brucei, mRNA processing is of particular importance, since most transcripts are derived from polycistronic transcription units. This organization dictates that regulated gene expression is promoter-independent and governed at the posttranscriptional level. We have identified tbCPSF30, a...

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Identifiers

PMID: 12746436
DOI: 10.1074/jbc.M302405200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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