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Article

Mechanistic rationale for targeting the unfolded protein response in pre-B acute lymphoblastic leukemia

12 May 2014

Abstract excerpt

The unfolded protein response (UPR) pathway, a stress-induced signaling cascade emanating from the endoplasmic reticulum (ER), regulates the expression and activity of molecules including BiP (HSPA5), IRE1 (ERN1), Blimp-1 (PRDM1), and X-box binding protein 1 (XBP1). These molecules are required for terminal differentiation of B cells into plasma cells and expressed at high levels in plasma cell-derived multiple...

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PMID: 24821775
DOI: 10.1073/pnas.1400958111

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