Article
The Amount of BCL6 in B Cells Shortly after Antigen Engagement Determines Their Representation in Subsequent Germinal Centers.
Cell reports - 4 Feb 2020
Robinson Marcus James, Ding Zhoujie, Pitt Catherine, Brodie Erica Janet, Quast Isaak, Tarlinton David Mathew, Zotos Dimitra
Abstract excerpt
It is unknown whether the incremental increases in BCL6 amounts in antigen-activated B cells influence the unfolding differentiation before germinal center (GC) formation. By comparing shortly after immunization the distribution of conventional B cells to those enforced to express BCL6 at the upper quartile of normal and those lacking BCL6 altogether, we determined that B cell representation in the stages before...
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