Article
Role for Bcl-6 in the generation and maintenance of memory CD8+ T cells.
Nature immunology - 1 Jun 2002
Ichii Hirohito, Sakamoto Akemi, Hatano Masahiko, Okada Seiji, Toyama Hirochika, Taki Shinsuke, Arima Masafumi, Kuroda Yoshikazu, Tokuhisa Takeshi
Abstract excerpt
Naïve T cells proliferate and differentiate into memory cells after antigenic stimulation or in a lymphopenic environment. We showed here transient increases in memory phenotype CD8+ T cell numbers in the lymphopenic environment of spleens of very young mice. The magnitude of the increase correlated with Bcl-6 expression in the T cells. Bcl-6 controlled the generation and maintenance of antigen-specific memory...
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