RGS7 is recurrently mutated in melanoma and promotes migration and invasion of human cancer cells.

doi:10.1038/s41598-017-18851-4

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Article

RGS7 is recurrently mutated in melanoma and promotes migration and invasion of human cancer cells.

Scientific reports - 12 Jan 2018

Qutob Nouar, Masuho Ikuo, Alon Michal, Emmanuel Rafi, Cohen Isadora, Di Pizio Antonella, Madore Jason, Elkahloun Abdel, Ziv Tamar, Levy Ronen, Gartner Jared J, Hill Victoria K, Lin Jimmy C, Hevroni Yael, Greenberg Polina, Brodezki Alexandra, Rosenberg Steven A, Kosloff Mickey, Hayward Nicholas K, Admon Arie, Niv Masha Y, Scolyer Richard A, Martemyanov Kirill A, Samuels Yardena

Abstract excerpt

Analysis of 501 melanoma exomes revealed RGS7, which encodes a GTPase-accelerating protein (GAP), to be a tumor-suppressor gene. RGS7 was mutated in 11% of melanomas and was found to harbor three recurrent mutations (p.R44C, p.E383K and p.R416Q). Structural modeling of the most common recurrent mutation of the three (p.R44C) predicted that it destabilizes the protein due to the loss of an H-bond and salt bridge...

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PMID: 29330521
DOI: 10.1038/s41598-017-18851-4
PMCID: PMC5766496

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RGS7

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