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Article

HBOC multi-gene panel testing: comparison of two sequencing centers.

Breast cancer research and treatment - 1 Jul 2015

Schroeder Christopher, Faust Ulrike, Sturm Marc, Hackmann Karl, Grundmann Kathrin, Harmuth Florian, Bosse Kristin, Kehrer Martin, Benkert Tanja, Klink Barbara, Mackenroth Luisa, Betcheva-Krajcir Elitza, Wimberger Pauline, Kast Karin, Heilig Mechthilde, Nguyen Huu Phuc, Riess Olaf, Schröck Evelin, Bauer Peter, Rump Andreas

Abstract excerpt

Multi-gene panels are used to identify genetic causes of hereditary breast and ovarian cancer (HBOC) in large patient cohorts. This study compares the diagnostic workflow in two centers and gives valuable insights into different next-generation sequencing (NGS) strategies. Moreover, we present data from 620 patients sequenced at both centers. Both sequencing centers are part of the German consortium for...

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Source

Identifiers

PMID: 26022348
DOI: 10.1007/s10549-015-3429-9

Genes

BRCA1
BRCA2
ATM
CDH1
CHEK2
NBN
PALB2

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