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Article

APOE and dementia - resequencing and genotyping in 105,597 individuals.

Alzheimer's & dementia : the journal of the Alzheimer's Association - 1 Dec 2020

Rasmussen Katrine L, Tybjaerg-Hansen Anne, Nordestgaard Børge G, Frikke-Schmidt Ruth

Abstract excerpt

INTRODUCTION: The mechanism behind the strong association between the ɛ2/ɛ3/ɛ4 apolipoprotein E gene (APOE) polymorphism and Alzheimer's disease is not well-characterized. Because low plasma levels of apoE associate with risk of dementia, genetic variants altering apoE levels in general may also associate with dementia. METHODS: The APOE gene was sequenced in 10,369 individuals, and nine amino acid-changing...

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Identifiers

PMID: 32808727
DOI: 10.1002/alz.12165
PMCID: PMC7984319

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