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Article

Inactivation of mesotrypsin by chymotrypsin C prevents trypsin inhibitor degradation.

The Journal of biological chemistry - 13 Mar 2020

Toldi Vanda, Szabó András, Sahin-Tóth Miklós

Abstract excerpt

Mesotrypsin is an unusual human trypsin isoform with inhibitor resistance and the ability to degrade trypsin inhibitors. Degradation of the protective serine protease inhibitor Kazal type 1 (SPINK1) by mesotrypsin in the pancreas may contribute to the pathogenesis of pancreatitis. Here we tested the hypothesis that the regulatory digestive protease chymotrypsin C (CTRC) mitigates the harmful effects of...

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Identifiers

PMID: 32014997
DOI: 10.1074/jbc.RA120.012526
PMCID: PMC7076226

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Inactivation of mesotrypsin by chymotrypsin C prevents trypsin inhibitor degradation.PMID 32014997Read ↗

Human Mesotrypsin Is a Unique Digestive Protease Specialized for the Degradation of Trypsin InhibitorsSemantic proximity Read ↗

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Human mesotrypsin exhibits restricted S1' subsite specificity with a strong preference for small polar side chains.Semantic proximity Read ↗

Mouse model suggests limited role for human mesotrypsin in pancreatitis.Semantic proximity Read ↗

Genetic and biochemical characterization of the E32del polymorphism in human mesotrypsinogen.Semantic proximity Read ↗

Autoactivation of mouse trypsinogens is regulated by chymotrypsin C via cleavage of the autolysis loop.Semantic proximity Read ↗

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