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Article

Mouse model suggests limited role for human mesotrypsin in pancreatitis.

Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] - 1 Mar 2021

Mosztbacher Dóra, Sahin-Tóth Miklós

Abstract excerpt

Mesotrypsin is a low-abundance human trypsin isoform with a unique evolutionary mutation that conferred resistance to trypsin inhibitors and restricted substrate specificity. Mesotrypsin degrades the serine protease inhibitor Kazal type 1 (SPINK1) and thereby might increase risk for pancreatitis. Here, we report a mouse model designed to test the role of mesotrypsin in pancreatitis. We introduced the human...

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Share to Chymotrypsin
Share to Gene Expression Regulation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Inflammation

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Share to Trypsin Inhibitor, Kazal Pancreatic

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Source

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Identifiers

PMID: 33526384
DOI: 10.1016/j.pan.2021.01.007
PMCID: PMC7969449

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