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Article

Inhibition of mouse trypsin isoforms by SPINK1 and effect of human pancreatitis-associated mutations.

Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] - 1 Jun 2023

Morales Granda Nataly C, Toldi Vanda, Miczi Márió, Lassoued Meriam, Szabó András

Abstract excerpt

Serine protease inhibitor Kazal type 1 (SPINK1) is a trypsin-selective inhibitor protein secreted by the exocrine pancreas. Loss-of-function SPINK1 mutations predispose to chronic pancreatitis through either reduced expression, secretion, or impaired trypsin inhibition. In this study, we aimed to characterize the inhibitory activity of mouse SPINK1 against cationic (T7) and anionic (T8, T9, T20) mouse trypsin...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 37149461
DOI: 10.1016/j.pan.2023.04.043

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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