Article
Human mesotrypsin defies natural trypsin inhibitors: from passive resistance to active destruction.
Protein and peptide letters - 1 Jul 2005
Sahin-Tóth Miklós
Abstract excerpt
More than twenty years ago Rinderknecht et al. identified a minor trypsin isoform resistant to natural trypsin inhibitors in the human pancreatic juice. At the same time, Estell and Laskowski found that an inhibitor-resistant trypsin from the pyloric caeca of the starfish, Dermasterias imbricata rapidly hydrolyzed the reactive-site peptide bonds of trypsin inhibitors. A connection between these two seminal...
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