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Article

Human mesotrypsin exhibits restricted S1' subsite specificity with a strong preference for small polar side chains.

The FEBS journal - 1 Jul 2006

Szepessy Edit, Sahin-Tóth Miklós

Abstract excerpt

Mesotrypsin, an inhibitor-resistant human trypsin isoform, does not activate or degrade pancreatic protease zymogens at a significant rate. These observations led to the proposal that mesotrypsin is a defective digestive protease on protein substrates. Surprisingly, the studies reported here with alpha1-antitrypsin (alpha1AT) revealed that, even though mesotrypsin was completely resistant to this serpin-type...

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Identifiers

PMID: 16759229
DOI: 10.1111/j.1742-4658.2006.05305.x
PMCID: PMC1550978

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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