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Article

Non-active site mutation (Q123A) in New Delhi metallo-β-lactamase (NDM-1) enhanced its enzyme activity.

International journal of biological macromolecules - 1 Jun 2018

Ali Abid, Azam Mohd W, Khan Asad U

Abstract excerpt

New Delhi metallo β-lactamase-1 is one of the carbapenemases, causing hydrolysis of almost all β-lactamase antibiotics. Seventeen different NDM variants have been reported so far, they varied in their sequences either by single or multiple amino acid substitutions. Hence, it is important to understand its structural and functional relation. In the earlier studies role of active site residues has been studied but...

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PMID: 29454953
DOI: 10.1016/j.ijbiomac.2018.02.091

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