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The effects of NDM-5 on Escherichia coli and the screening of interacting proteins

30 Jan 2024

Abstract excerpt

Carbapenem-resistant Escherichia coli (E. coli) strains are widely distributed and spreading rapidly, creating significant challenges for clinical therapeutics. NDM-5, a novel mutant of New Delhi Metallo-β-Lactamase-1 (NDM-1), exhibits high hydrolase activity toward carbapenems. Since the genetic backgrounds of clinically isolated carbapenem-resistant E. coli are heterogeneous, it is difficult to accurately...

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PMID: 38348193
DOI: 10.3389/fmicb.2024.1328572

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