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Article

The directed evolution of NDM-1

24 Oct 2023

Abstract excerpt

ABSTRACT β-Lactam antibiotics are among the most frequently prescribed therapeutic agents. A common mechanism of resistance toward β-lactam antibiotics is the production of β-lactamases. These enzymes are capable of hydrolyzing the β-lactam bond, rendering the drug inactive. Among the four described classes, the metallo- β-lactamases (MBLs, class B) employ one or two zinc ions in the active site for catalysis....

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Share to Antibiotic Resistance in Bacteria
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PMID: 37874296
DOI: 10.1128/aac.00714-23

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