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Article

A landscape of genomic alterations at the root of a near-untreatable tuberculosis epidemic.

BMC medicine - 4 Feb 2020

Klopper Marisa, Heupink Tim Hermanus, Hill-Cawthorne Grant, Streicher Elizabeth Maria, Dippenaar Anzaan, de Vos Margaretha, Abdallah Abdallah Musa, Limberis Jason, Merker Matthias, Burns Scott, Niemann Stefan, Dheda Keertan, Posey James, Pain Arnab, Warren Robin Mark

Abstract excerpt

BACKGROUND: Atypical Beijing genotype Mycobacterium tuberculosis strains are widespread in South Africa and have acquired resistance to up to 13 drugs on multiple occasions. It is puzzling that these strains have retained fitness and transmissibility despite the potential fitness cost associated with drug resistance mutations. METHODS: We conducted Illumina sequencing of 211 Beijing genotype M. tuberculosis...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32014024
DOI: 10.1186/s12916-019-1487-2
PMCID: PMC6998097

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