Comparative whole genome analysis of Mycobacterium tuberculosis isolated from BPaLM and individualized regimen treated patients at Dr. Soetomo Hospital, Indonesia.

doi:10.1007/s11033-026-12652-7

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Comparative whole genome analysis of Mycobacterium tuberculosis isolated from BPaLM and individualized regimen treated patients at Dr. Soetomo Hospital, Indonesia.

Molecular biology reports - 24 Aug 2026

Setyawan Muhamad Frendy, Shaban Amina K, Takihara Hayato, Tateishi Yoshitaka, Nishiyama Akihito, Ozeki Yuriko, Nuha Zakiyathun, Mertaniasih Ni Made, Okuda Shujiro, Soedarsono Soedarsono, Omrani Maryam, Rukminiati Yuni, Merdekawati Ummi Amaliatush Sholichah Putri, Artama Wayan Tunas, Matsumoto Sohkichi

Abstract excerpt

BACKGROUND: The World Health Organization (WHO) recommends whole genome sequencing (WGS) to support the detection of drug-resistant tuberculosis and the use of the new regimen BPaLM (Bedaquiline-Pretomanid-Linezolid-Moxifloxacin) to treat drug-resistant tuberculosis (TB). Genomic profiles of Mycobacterium tuberculosis (MTB) are needed to understand the regimen's future impact comprehensively. METHODS: In this...

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PMID: 42635856
DOI: 10.1007/s11033-026-12652-7

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