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Article

The Hidden Epidemic of Isoniazid-Resistant Tuberculosis in South Africa.

Annals of the American Thoracic Society - 1 Oct 2024

Klopper Marisa, van der Merwe Charnay J, van der Heijden Yuri F, Folkerts Megan, Loubser Johannes, Streicher Elizabeth M, Mekler Kate, Hayes Cindy, Engelthaler David M, Metcalfe John Z, Warren Robin M

Abstract excerpt

Rationale: Isoniazid-resistant tuberculosis (Hr-TB) is often overlooked in diagnostic algorithms because of reliance on first-line molecular assays testing only for rifampicin resistance. Objectives: To determine the prevalence, outcomes, and molecular mechanisms associated with rifampin-susceptible, isoniazid-resistant TB (Hr-TB) in the Eastern Cape, South Africa. Methods: Between April 2016 and October 2017,...

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Identifiers

PMID: 38935769
DOI: 10.1513/AnnalsATS.202312-1076OC
PMCID: PMC11451881

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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