Article
The non-clonality of drug resistance in Beijing-genotype isolates of Mycobacterium tuberculosis from the Western Cape of South Africa.
BMC genomics - 26 Nov 2010
Ioerger Thomas R, Feng Yicheng, Chen Xiaohua, Dobos Karen M, Victor Thomas C, Streicher Elizabeth M, Warren Robin M, Gey van Pittius Nicolaas C, Van Helden Paul D, Sacchettini James C
Abstract excerpt
BACKGROUND: The Beijing genotype of M. tuberculosis is a virulent strain that is disseminating worldwide and has a strong association with drug resistance. In the Western Cape of South Africa, epidemiological studies have identified the R220 cluster of the Beijing genotype as a major contributor to a recent outbreak of drug-resistant tuberculosis. Although the outbreak is considered to be due to clonal...
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