Article
Emergence and spread of extensively and totally drug-resistant tuberculosis, South Africa.
Emerging infectious diseases - 1 Mar 2013
Klopper Marisa, Warren Robin Mark, Hayes Cindy, Gey van Pittius Nicolaas Claudius, Streicher Elizabeth Maria, Müller Borna, Sirgel Frederick Adriaan, Chabula-Nxiweni Mamisa, Hoosain Ebrahim, Coetzee Gerrit, David van Helden Paul, Victor Thomas Calldo, Trollip André Phillip
Abstract excerpt
Factors driving the increase in drug-resistant tuberculosis (TB) in the Eastern Cape Province, South Africa, are not understood. A convenience sample of 309 drug-susceptible and 342 multidrug-resistant (MDR) TB isolates, collected July 2008-July 2009, were characterized by spoligotyping, DNA fingerprinting, insertion site mapping, and targeted DNA sequencing. Analysis of molecular-based data showed diverse...
Topics
- Antitubercular Agents
- Bacterial Proteins
- Catalase
- Cluster Analysis
- Communicable Diseases, Emerging
- Extensively Drug-Resistant Tuberculosis
- Genotype
- Humans
- Microbial Sensitivity Tests
- Mutation, Missense
- Mycobacterium tuberculosis