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Myelodysplastic syndromes: Updates on Genomic Landscape, Molecular Subtypes, & Targeted Therapies.

Current hematologic malignancy reports - 27 Oct 2025

Mo Shirley S, DeZern Amy E

Abstract excerpt

PURPOSE OF REVIEW: Advances in modern molecular and genomic testing have spurred tremendous progress in our understanding of MDS pathogenesis. Here we review common diagnostic methods, the evolving multi-omics landscape of MDS, molecular subtypes, and targeted therapies. RECENT FINDINGS: MDS is a heterogeneous disease defined by a wide array of chromosomal abnormalities and > 40 common somatic mutations affecting...

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Identifiers

PMID: 41143913
DOI: 10.1007/s11899-025-00762-1
PMCID: PMC13195416

Genes

TP53
IDH1
SF3B1

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