Article
β-Lapachone promotes the recruitment and polarization of tumor-associated neutrophils (TANs) toward an antitumor (N1) phenotype in NQO1-positive cancers.
Oncoimmunology - 1 Jan 2024
Tumbath Soumya, Jiang Lingxiang, Li Xiaoguang, Zhang Taolan, Zahid Kashif Rafiq, Zhao Ye, Zhou Hao, Yin Zhijun, Lu Tao, Jiang Shu, Chen Yaomin, Chen Xiang, Fu Yang-Xin, Huang Xiumei
Abstract excerpt
NAD(P)H:quinone oxidoreductase 1 (NQO1) is overexpressed in most solid cancers, emerging as a promising target for tumor-selective killing. β-Lapachone (β-Lap), an NQO1 bioactivatable drug, exhibits significant antitumor effects on NQO1-positive cancer cells by inducing immunogenic cell death (ICD) and enhancing tumor immunogenicity. However, the interaction between β-Lap-mediated antitumor immune responses and...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.