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Article

NAD(P)H:Quinone Oxidoreductase-1 Expression Sensitizes Malignant Melanoma Cells to the HSP90 Inhibitor 17-AAG.

PloS one - 1 Jan 2016

Kasai Shuya, Arakawa Nobuyuki, Okubo Ayaka, Shigeeda Wataru, Yasuhira Shinji, Masuda Tomoyuki, Akasaka Toshihide, Shibazaki Masahiko, Maesawa Chihaya

Abstract excerpt

The KEAP1-NRF2 pathway regulates cellular redox homeostasis by transcriptional induction of genes associated with antioxidant synthesis and detoxification in response to oxidative stress. Previously, we reported that KEAP1 mutation elicits constitutive NRF2 activation and resistance to cisplatin (CDDP) and dacarbazine (DTIC) in human melanomas. The present study was conducted to clarify whether an HSP90...

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Source

Open in PubMed Open full text

Identifiers

PMID: 27045471
DOI: 10.1371/journal.pone.0153181
PMCID: PMC4821458

Genes

KEAP1
NQO1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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NAD(P)H:Quinone Oxidoreductase-1 Expression Sensitizes Malignant Melanoma Cells to the HSP90 Inhibitor 17-AAG.PMID 27045471Read ↗

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