Genomic landscape of drug binding and pharmacogenetic variation across diverse populations using SNPdrug3D.

doi:10.1038/s41467-026-73816-4

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Genomic landscape of drug binding and pharmacogenetic variation across diverse populations using SNPdrug3D.

Nature communications - 9 Jun 2026

Malik Ashar J, Kenanov Dimitar, Chong Cheng-Shoong, Ozturk Mert Burak, Wang Qiqi, Chang Hong-Yun, Hebrard Maxime, Ho Ying Swan, Wang Zhenxun, Limviphuvadh Vachiranee, Miyajima Jhoann M T, Kannan Srinivasaraghavan, Magallanes Roberto Tirado, Sim Xueling, Chai Jin Fang, Davila Sonia, Yeo Khung Keong, Leong Khai Pang, Goh Liuh Ling, Karnani Neerja, Eriksson Johan Gunnar, Cheng Ching-Yu, Wong Tien Yin, Loh Marie, Dalan Rinkoo, Khor Chiea Chuen, Chew Guo-Liang, Lim Weng Khong, Ngeow Joanne, Chambers John C, Tai E Shyong, Bertin Nicolas, Tan Chris Soon Heng, Koh Judice, Tan Patrick, Verma Chandra S, Maurer-Stroh Sebastian

Abstract excerpt

One of the promises of precision medicine is to understand and act on inter-individual genetic differences in drug responses. SNPdrug3D contains the complete genomic landscape of missense single nucleotide variants (SNV) across the human proteome and at a population-wide level that could affect drug binding. Here, we map SNVs in over 80,000 individuals from the Singapore SG10K Health and gnomAD cohorts to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cytochrome P-450 Enzyme System

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genomics

Share to Pharmaceutical Preparations

Share to Pharmacogenetics

Share to Pharmacogenomic Variants

Share to Precision Medicine

Share to Protein Binding

Share to Singapore

Source

Open in PubMed Open full text

Identifiers

PMID: 42265106
DOI: 10.1038/s41467-026-73816-4
PMCID: PMC13402600

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genomic landscape of drug binding and pharmacogenetic variation across diverse populations using SNPdrug3D.PMID 42265106Read ↗

Genomic landscape of drug binding and pharmacogenetic variation across diverse populations using SNPdrug3DSemantic proximity Read ↗

Supporting precision medicine by data mining across multi-disciplines: an integrative approach for generating comprehensive linkages between single nucleotide variants (SNVs) and drug-binding sites.Semantic proximity Read ↗

Genomic analysis of human polymorphisms affecting drug-protein interactionsSemantic proximity Read ↗

PharmGKB: understanding the effects of individual genetic variants.Semantic proximity Read ↗

Whole genome sequencing identifies high-impact variants in well-known pharmacogenomic genes.Semantic proximity Read ↗

Impact of germline and somatic missense variations on drug binding sites.Semantic proximity Read ↗

Whole genome sequencing identifies high-impact variants in well-known pharmacogenomic genesSemantic proximity Read ↗

Genetic variation in human drug-related genesSemantic proximity Read ↗

PGMD: a comprehensive manually curated pharmacogenomic database.Semantic proximity Read ↗

Targeted Next-Generation Sequencing for Comprehensive Genetic Profiling of Pharmacogenes.Semantic proximity Read ↗

Machine learning models for pharmacogenomic variant effect predictions - recent developments and future frontiers.Semantic proximity Read ↗

Global spectrum of population-specific common missense variation in cytochrome P450 pharmacogenes.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.