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Article

Structural basis of second-generation HIV integrase inhibitor action and viral resistance.

Science (New York, N.Y.) - 14 Feb 2020

Cook Nicola J, Li Wen, Berta Dénes, Badaoui Magd, Ballandras-Colas Allison, Nans Andrea, Kotecha Abhay, Rosta Edina, Engelman Alan N, Cherepanov Peter

Abstract excerpt

Although second-generation HIV integrase strand-transfer inhibitors (INSTIs) are prescribed throughout the world, the mechanistic basis for the superiority of these drugs is poorly understood. We used single-particle cryo-electron microscopy to visualize the mode of action of the advanced INSTIs dolutegravir and bictegravir at near-atomic resolution. Glutamine-148→histidine (Q148H) and glycine-140→serine (G140S)...

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Identifiers

PMID: 32001525
DOI: 10.1126/science.aay4919
PMCID: PMC7023979

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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