Article

Remdesivir is a Delayed Translocation Inhibitor of SARS CoV-2 Replication

2020-12-15

Abstract excerpt

Remdesivir is a nucleoside analog approved by the FDA for treatment of COVID-19. Here, we present a 3.9-Å-resolution cryoEM reconstruction of a remdesivir-stalled RNA-dependent RNA polymerase complex, revealing full incorporation of three copies of remdesivir monophosphate (RMP) and a partially incorporated fourth RMP in the active site. The structure reveals that RMP blocks RNA translocation after incorporatio...

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Literature Corpus work: 0154a301-3186-5e0b-8f11-73f737980717
DOI: 10.2139/ssrn.3749649

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