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Article

Molecular mechanisms of retroviral integrase inhibition and the evolution of viral resistance.

Proceedings of the National Academy of Sciences of the United States of America - 16 Nov 2010

Hare Stephen, Vos Ann M, Clayton Reginald F, Thuring Jan W, Cummings Maxwell D, Cherepanov Peter

Abstract excerpt

The development of HIV integrase (IN) strand transfer inhibitors (INSTIs) and our understanding of viral resistance to these molecules have been hampered by a paucity of available structural data. We recently reported cocrystal structures of the prototype foamy virus (PFV) intasome with raltegrav...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 21030679
DOI: 10.1073/pnas.1010246107
PMCID: PMC2993412

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-21030679-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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