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Article

Resistance to HIV-1 integrase inhibitors: A structural perspective.

Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy - 1 Jan 2000

Mouscadet Jean-François, Delelis Olivier, Marcelin Anne-Geneviève, Tchertanov Luba

Abstract excerpt

Strand-transfer inhibitors, of which raltegravir, elvitegravir and S/GSK1349572, is a new class of antiretrovirals that inhibit HIV integrase-catalyzed insertion of the HIV-1 genome into cell chromosomes. The results of clinical trials were very encouraging regarding their viral efficiency and tolerance. However resistance mutations were identified in patients failing to respond to treatment with these...

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Topics

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Share to HIV-1
Share to DNA, Viral
Share to Drug Resistance, Viral

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to HIV Infections

Share to HIV Integrase

Share to HIV Integrase Inhibitors

Share to Protein Conformation

Share to Protein Multimerization

Source

Identifiers

PMID: 20570551
DOI: 10.1016/j.drup.2010.05.001

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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