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Article

Structural and functional analyses of the second-generation integrase strand transfer inhibitor dolutegravir (S/GSK1349572).

Molecular pharmacology - 1 Oct 2011

Hare Stephen, Smith Steven J, Métifiot Mathieu, Jaxa-Chamiec Albert, Pommier Yves, Hughes Stephen H, Cherepanov Peter

Abstract excerpt

Raltegravir (RAL) and related HIV-1 integrase (IN) strand transfer inhibitors (INSTIs) efficiently block viral replication in vitro and suppress viremia in patients. These small molecules bind to the IN active site, causing it to disengage from the deoxyadenosine at the 3' end of viral DNA. The emergence of viral strains that are highly resistant to RAL underscores the pressing need to develop INSTIs with...

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Identifiers

PMID: 21719464
DOI: 10.1124/mol.111.073189
PMCID: PMC3187526

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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