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Article

Biochemical analysis of the role of G118R-linked dolutegravir drug resistance substitutions in HIV-1 integrase.

Antimicrobial agents and chemotherapy - 1 Dec 2013

Quashie Peter K, Mesplède Thibault, Han Ying-Shan, Veres Tamar, Osman Nathan, Hassounah Said, Sloan Richard D, Xu Hong-Tao, Wainberg Mark A

Abstract excerpt

Drug resistance mutations (DRMs) have been reported for all currently approved anti-HIV drugs, including the latest integrase strand transfer inhibitors (INSTIs). We previously used the new INSTI dolutegravir (DTG) to select a G118R integrase resistance substitution in tissue culture and also showed that secondary substitutions emerged at positions H51Y and E138K. Now, we have characterized the impact of the...

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Identifiers

PMID: 24080645
DOI: 10.1128/AAC.01835-13
PMCID: PMC3837891

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Biochemical analysis of the role of G118R-linked dolutegravir drug resistance substitutions in HIV-1 integrase.PMID 24080645Read ↗

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