Article
Frank-ter Haar syndrome protein Tks4 regulates epidermal growth factor-dependent cell migration.
The Journal of biological chemistry - 7 Sept 2012
Bögel Gábor, Gujdár Annamária, Geiszt Miklós, Lányi Árpád, Fekete Anna, Sipeki Szabolcs, Downward Julian, Buday László
Abstract excerpt
Mutations in the SH3PXD2B gene coding for the Tks4 protein are responsible for the autosomal recessive Frank-ter Haar syndrome. Tks4, a substrate of Src tyrosine kinase, is implicated in the regulation of podosome formation. Here, we report a novel role for Tks4 in the EGF signaling pathway. In EGF-treated cells, Tks4 is tyrosine-phosphorylated and associated with the activated EGF receptor. This association is...
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