Article

Epithelial-intrinsic nitric oxide synthase 2 sustains host-microbiota dynamics that promote colitis

2025-09-25

Abstract excerpt

<h4>ABSTRACT</h4> The microbiota influence disease pathogenesis and treatment, however we have limited ability to assess patient status in relation to the microbiota. Here we find that the nitric oxide generating enzyme, nitric oxide synthase 2 (Nos2), is transcriptionally primed in intestinal epithelial cells (IECs), as opposed to immune cells, in inflammatory bowel disease (IBD) patients. Generation of IEC-spec...

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Literature Corpus work: e222bf94-30a8-53f3-81d7-11fdaeb3a00f
DOI: 10.1101/2025.09.23.677925

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