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Article

Phenotypic characteristics of asthma and morbidity are associated with distinct longitudinal changes in L-arginine metabolism.

BMJ open respiratory research - 1 Jun 2023

Althoff Meghan Dolan, Peterson Ryan, McGrath Max, Jin Ying, Grasemann Hartmut, Sharma Sunita, Federman Alex, Wisnivesky Juan Pablo, Holguin Fernando

Abstract excerpt

BACKGROUND: The L-arginine metabolome is dysregulated in asthma, though it is not understood how longitudinal changes in L-arginine metabolism differ among asthma phenotypes and relate to disease outcomes. OBJECTIVES: To determine the longitudinal associations between phenotypic characteristics with L-arginine metabolites and their relationships with asthma morbidity. METHODS: This is a prospective cohort study...

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Identifiers

PMID: 37270184
DOI: 10.1136/bmjresp-2023-001683
PMCID: PMC10254613

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