Article
Construction of a pneumolysin deficient mutant in streptococcus pneumoniae serotype 1 strain 519/43 and phenotypic characterisation.
Microbial pathogenesis - 1 Apr 2020
Terra Vanessa S, Plumptre Charles D, Wall Emma C, Brown Jeremy S, Wren Brendan W
Abstract excerpt
Streptococcus pneumoniae capsular serotype 1 continues to pose a huge infectious disease burden in low- and middle-income countries, particularly in West Africa. However, studies on this important serotype have been hampered by the inability to genetically modify these strains. In this study we have genetically modified a serotype 1 strain (519/43), the first time that this has been achieved for this serotype,...
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