Article
An M protein with a single C repeat prevents phagocytosis of Streptococcus pyogenes: use of a temperature-sensitive shuttle vector to deliver homologous sequences to the chromosome of S. pyogenes.
Molecular microbiology - 1 May 1993
Perez-Casal J, Price J A, Maguin E, Scott J R
Abstract excerpt
The major virulence factor of the important human pathogen Streptococcus pyogenes is the M protein, which prevents phagocytosis of the bacterium. In different strains of streptococci, there are over 80 serologically different M proteins and there are additional M-like proteins, some of which bind...
Topics
- Alleles
- Antigens, Bacterial
- Bacterial Outer Membrane Proteins
- Bacterial Proteins
- Carrier Proteins
- Chromosomes, Bacterial
- Genes, Bacterial
- Genes, Synthetic
- Genetic Vectors
- Humans
- Mutagenesis, Site-Directed
- Phagocytosis
- Recombinant Fusion Proteins
- Repetitive Sequences, Nucleic Acid