Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Pneumolysin with low hemolytic activity confers an early growth advantage to Streptococcus pneumoniae in the blood.

Infection and immunity - 1 Oct 2011

Harvey Richard M, Ogunniyi Abiodun D, Chen Austen Y, Paton James C

Abstract excerpt

Streptococcus pneumoniae is a leading cause of human diseases such as pneumonia, bacteremia, meningitis, and otitis media. Pneumolysin (Ply) is an important virulence factor of S. pneumoniae and a promising future vaccine target. However, the expansion of clones carrying ply alleles with reduced hemolytic activity has been observed in serotypes associated with outbreaks of invasive disease and includes an allele...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Animals, Outbred Strains
Share to Bacteremia

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hemolysis

Share to Immunization

Share to Pneumococcal Infections

Share to Streptococcus pneumoniae

Share to Streptolysins

Source

Open in PubMed Open full text

Identifiers

PMID: 21788389
DOI: 10.1128/IAI.05418-11
PMCID: PMC3187248

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Pneumolysin with low hemolytic activity confers an early growth advantage to Streptococcus pneumoniae in the blood.PMID 21788389Read ↗

Presence of nonhemolytic pneumolysin in serotypes of Streptococcus pneumoniae associated with disease outbreaks.Semantic proximity Read ↗

Hypervirulent pneumococcal serotype 1 harbours two pneumolysin variants with differential haemolytic activitySemantic proximity Read ↗

Pneumolysin: Pathogenesis and Therapeutic TargetSemantic proximity Read ↗

Detoxified pneumolysin derivative Plym2 directly protects against pneumococcal infection via induction of inflammatory cytokines.Semantic proximity Read ↗

The Global Burden of Community-Acquired Pneumonia, Encompassing Invasive Pneumococcal Disease and the Prevalence of Its Associated Cardiovascular Events, With a Focus on Pneumolysin and Macrolide Antibiotics in Pathogenesis and TherapySemantic proximity Read ↗

Phenotypic characterisation of pneumococcal serotype-1 variants presenting low haemolytic activitySemantic proximity Read ↗

The NLRP3 inflammasome is differentially activated by pneumolysin variants and contributes to host defense in pneumococcal pneumonia.Semantic proximity Read ↗

MOLECULAR ANALYSIS OF THE PATHOGENICITY OF STREPTOCOCCUS PNEUMONIAE: The Role of Pneumococcal ProteinsSemantic proximity Read ↗

Identification of novel pneumolysin alleles from paediatric carriage isolates of Streptococcus pneumoniae.Semantic proximity Read ↗

Pneumolysin: A Double-Edged Sword During the Host-Pathogen InteractionSemantic proximity Read ↗

Pneumococcal lipoproteins involved in bacterial fitness, virulence, and immune evasionSemantic proximity Read ↗

Targeted control of pneumolysin production by a mobile genetic element in Streptococcus pneumoniaeSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.