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IL1β, IL18, NFKB1 and IFNG gene interactions are associated with severity of rheumatoid arthritis: A pilot study.

Autoimmunity - 1 Mar 2020

Gomes da Silva Isaura Isabelle Fonseca, Lima Camilla Albertina Dantas, Monteiro Maria Larissa Andrade, Barboza Daniella Alves Silva Pimentel, Rushansky Eliezer, Mariano Maria Helena Queiroz de Araújo, Sandrin-Garcia Paula, de Souza Paulo Roberto Eleutério, Maia Maria de Mascena Diniz

Abstract excerpt

Rheumatoid arthritis (RA) is an autoimmune disease which can lead to progressive and functional disability. Literature data suggest that some inflammatory proteins are dysregulated in RA patients and its genetic polymorphisms may contribute to the aetiology and pathogenesis of disease in different ethnic groups. Polymorphisms in IL1β, IL18, NFKB1 and IFNG genes were studied in different populations with RA, but...

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PMID: 31992083
DOI: 10.1080/08916934.2019.1710831

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