Article
Interleukin-18, interleukin-12B and interferon-γ gene polymorphisms in Brazilian patients with rheumatoid arthritis: a pilot study.
Tissue antigens - 1 Oct 2015
Angelo H D, Gomes Silva I I F, Oliveira R D R, Louzada-Júnior P, Donadi E A, Crovella S, Maia M M D, de Souza P R E, Sandrin-Garcia P
Abstract excerpt
Polymorphisms in interleukin (IL)-18, IL-12 and interferon (IFN)-γ genes are associated with different levels of cytokines expression and have been associated with rheumatoid arthritis (RA). IL-18 +105 A/C, IL-12B +1188 A/C and IFN-γ +874 T/A polymorphisms were analyzed by restriction fragment length polymorphism-polymerase chain reaction (PCR) and amplification refractory mutation system PCR from 90 RA patients...
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