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Article

Influence of IL10 and TGFB1 Promoter Polymorphisms on Serum Cytokine Levels in Development and Severity of RA.

International journal of molecular sciences - 8 Oct 2022

Vasilev Georgi, Ivanova Mariana, Stanilov Iskren, Miteva Lyuba, Stanilova Spaska, Manolova Irena

Abstract excerpt

In our study, we focused on the role of the immunosuppressive cytokines TGF-β1 and IL-10 in RA and, in particular, the influence of the IL10-1082 A/G (rs1800896) and TGFB1-509C/T (rs1800469) promoter polymorphisms on their levels as a prerequisite for RA and disease activity clinical features. We found significantly higher IL-10 and lower TGF-β1 serum levels in women with RA than in controls. Patients who carried...

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Share to Arthritis, Rheumatoid
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Share to Genetic Predisposition to Disease
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Identifiers

PMID: 36233253
DOI: 10.3390/ijms231911955
PMCID: PMC9570288

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