Article
Interleukin-18 gene (IL18) promoter polymorphisms in patients with rheumatoid arthritis.
Scandinavian journal of rheumatology - 1 Jan 2000
Pawlik A, Kurzawski M, Drozdzik M, Dziedziejko V, Safranow K, Herczynska M
Abstract excerpt
OBJECTIVE: Rheumatoid arthritis (RA) is a complex autoimmune disease with a strong genetic contribution to its pathogenesis. Proinflammatory cytokines play an important role in the inflammatory process in RA patients. The synthesis of cytokines is genetically determined. Cytokine gene polymorphisms have been implicated in a number of diseases, including RA. Interleukin-18 (IL-18) is a proinflammatory cytokine...
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