Impact of IL6 and IL18 Promoter Polymorphisms on Circulating Cytokine Levels, Gene Expression, and Susceptibility to Rheumatoid Arthritis.

doi:10.3390/ijms27167132

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Article

Impact of IL6 and IL18 Promoter Polymorphisms on Circulating Cytokine Levels, Gene Expression, and Susceptibility to Rheumatoid Arthritis.

International journal of molecular sciences - 9 Aug 2026

Vasileva Viktoria, Vasilev Georgi, Ivanova Mariana, Miteva Lyuba, Manolova Irena

Abstract excerpt

Our study examined the impact of IL6 -174 G/C (rs1800795) and IL18 -607 C/A (rs1946518) promoter polymorphisms on susceptibility to rheumatoid arthritis (RA) and protein/mRNA levels. RA patients had significantly higher serum IL-6 and IL-18 levels than controls; healthy men had higher IL-18 than women (p < 0.001). Conversely, IL6 mRNA expression was lower in RA patients than controls (p = 0.037). No link was...

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Alleles
Arthritis, Rheumatoid
Case-Control Studies
Interleukin-18

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Interleukin-6

Polymorphism, Single Nucleotide

Promoter Regions, Genetic

RNA, Messenger

Source

Open in PubMed Open full text

Identifiers

PMID: 42653136
DOI: 10.3390/ijms27167132
PMCID: PMC13513842

Genes

IL6
IL18

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.