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Article

Toll-like receptor (TLR2 and TLR4) polymorphisms and chronic obstructive pulmonary disease.

PloS one - 1 Jan 2012

Budulac Simona E, Boezen H Marike, Hiemstra Pieter S, Lapperre Therese S, Vonk Judith M, Timens Wim, Postma Dirkje S

Abstract excerpt

Toll-like receptors (TLRs) participate in the defence against bacterial infections that are common in patients with Chronic Obstructive Pulmonary Disease (COPD). We studied all tagging SNPs in TLR2 and TLR4 and their associations with the level and change over time of both FEV(1) and sputum inflammatory cells in moderate-to-severe COPD. Nine TLR2 SNPs and 17 TLR4 SNPs were genotyped in 110 COPD patients....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22952638
DOI: 10.1371/journal.pone.0043124
PMCID: PMC3429472

Genes

FEV
TLR2
TLR4

Provenance

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